Santiago-Fernandez, ConcepcionMartin-Reyes, FloresTome, MonicaGutierrez-Repiso, CarolinaFernandez-Garcia, DiegoOcana-Wilhelmi, LuisRivas-Becerra, JoseTatzber, FranzPursch, EdithTinahones, Francisco J.Garcia-Fuentes, EduardoGarrido-Sanchez, Lourdes2025-01-072025-01-072021-11-01https://hdl.handle.net/10668/27079Background: Little is known about the effects of hypoxia on scavenger receptors (SRs) levels in adipocytes. We analyzed the effect of morbid obesity and hypoxia on SRs and inflammation markers in human visceral adipocytes and whether ox-LDL modify the inflammatory profile produced by hypoxia. Methods: We studied in 17 non-obese and 20 subjects with morbid obesity (MO) the mRNA expression of HIF-1 alpha, SRs (LOX-1, MSR1, CL-P1 and CXCL16), IL6 and TNF alpha in visceral adipocytes and the effect of hypoxia with or without ox-LDL on visceral in vitro-differentiated adipocytes (VDA). Results: HIF-1 alpha, TNF alpha, IL6, LOX-1, MSR1 and CXCL16 expression in adipocytes was increased in MO when compared with those in non-obese subjects (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/hypoxiascavenger receptorsoxidized LDLadipocytesmorbid obesityLow-density-lipoproteinAdipose-tissueInsulin-resistanceOxidative stressScavenger receptorsFatty-acidsExpressionInflammationObesityAtherosclerosisresearch article34829944open access10.3390/biomedicines91117152227-9059https://www.mdpi.com/2227-9059/9/11/1715/pdf?version=1637239601724191700001