Rodríguez-Pérez, María DoloresLópez-Villodres, Juan AntonioArrebola, María MonsaludMartín-Aurioles, EstherFernández-Prior, ÁfricaBermúdez-Oria, AlejandraRíos, María CarmenDe La Cruz, José PedroGonzález-Correa, José Antonio2025-01-072025-01-072021-11-082076-3921https://hdl.handle.net/10668/26786The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/diabeteshydroxytyrosolnephropathyvirgin olive oilresearch article34829654open access10.3390/antiox10111783PMC8615082https://www.mdpi.com/2076-3921/10/11/1783/pdf?version=1636355496https://pmc.ncbi.nlm.nih.gov/articles/PMC8615082/pdf