Martin-Piedra, LauraAlcala-Diaz, Juan F.Gutierrez-Mariscal, Francisco M.Arenas de Larriva, Antonio P.Romero-Cabrera, Juan L.Torres-Pena, Jose D.Caballero-Villarraso, JavierLuque, Raul M.Perez-Martinez, PabloLopez-Miranda, JoseDelgado-Lista, Javier2025-01-072025-01-072021-11-01https://hdl.handle.net/10668/25863Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/obesity metabolic phenotypesmetabolically healthy obesemetabolically unhealthy obesefatty liver indexdiet interventionMediterranean dietlow-fat dietcoronary patientsBody-fat distributionHealthy obesityAdipose-tissueCardiovascular-diseaseEuropean-societyTask-forceInflammationAssociationPreventionMassresearch article34836298open access10.3390/nu131140462072-6643https://www.mdpi.com/2072-6643/13/11/4046/pdf?version=1636714455723789500001