Molina-Vega, MaríaRodríguez-Pérez, Carlos AntonioÁlvarez-Mancha, Ana IsabelBaena-Nieto, GloriaRiestra, MaríaAlcázar, VictoriaRomero-Lluch, Ana ReyesGalofré, Juan CFernández-García, José C2025-01-072025-01-072019-12-092077-0383https://hdl.handle.net/10668/27789Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs. A retrospective cross-sectional multicenter study including data from four HR-TNCs in Spain. We evaluated fine-needle aspiration (FNA) indications and the association between clinical and ultrasound characteristics with cytological and histopathological outcomes. A total of 2809 thyroid nodules were included; FNA was performed in 82.1%. Thyroid nodules that underwent FNA were more likely larger, isoechoic, with microcalcifications, and in younger subjects. The rate of nondiagnostic FNA was 4.3%. A solid component, irregular margins or microcalcifications, significantly increased the odds of Bethesda IV-V-VI (vs. Bethesda II). Irregular margins and a solid component were independently associated with increased odds of malignancy. Thyroid nodules In this large multicenter study, we found that the presence of a solid component and irregular margins are factors independently related to malignancy in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy, this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with a low rate of nondiagnostic FNA.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/fine needle aspirationthyroid nodulesultrasoundresearch article31818026open access10.3390/jcm8122172PMC6947274https://www.mdpi.com/2077-0383/8/12/2172/pdf?version=1576826036https://pmc.ncbi.nlm.nih.gov/articles/PMC6947274/pdf