Molina-Vega, MariaRodriguez-Perez, Carlos AntonioAlvarez-Mancha, Ana IsabelBaena-Nieto, GloriaRiestra, MariaAlcazar, VictoriaRomero-Lluch, Ana ReyesGalofre, Juan CFernandez-Garcia, Jose C2025-01-072025-01-072019-12-09Molina-Vega M, Rodríguez-Pérez CA, Álvarez-Mancha AI, Baena-Nieto G, Riestra M, Alcázar V, et al. Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics. J Clin Med. 2019 Dec 9;8(12):2172.2077-0383https://hdl.handle.net/10668/27789Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs. A retrospective cross-sectional multicenter study including data from four HR-TNCs in Spain. We evaluated fine-needle aspiration (FNA) indications and the association between clinical and ultrasound characteristics with cytological and histopathological outcomes. A total of 2809 thyroid nodules were included; FNA was performed in 82.1%. Thyroid nodules that underwent FNA were more likely larger, isoechoic, with microcalcifications, and in younger subjects. The rate of nondiagnostic FNA was 4.3%. A solid component, irregular margins or microcalcifications, significantly increased the odds of Bethesda IV-V-VI (vs. Bethesda II). Irregular margins and a solid component were independently associated with increased odds of malignancy. Thyroid nodules In this large multicenter study, we found that the presence of a solid component and irregular margins are factors independently related to malignancy in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy, this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with a low rate of nondiagnostic FNA.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/fine needle aspirationthyroid nodulesultrasoundThyroid NodulesClinics, SpecializedFine-Needle BiopsyUltrasonographyCytodiagnosisHistologyThyroid Neoplasms / surgeryNeoplasm ProteinsRisk AssessmentPrognosisresearch article31818026open accessNódulos tiroideosClínicas especializadasBiopsia por aspiración con aguja finaUltrasonografíaCitodiagnósticoHistologíaNeoplasias tiroideas / cirugíaProteínas de neoplasiaEvaluación de riesgoPronóstico10.3390/jcm8122172PMC6947274https://www.mdpi.com/2077-0383/8/12/2172/pdf?version=1576826036https://pmc.ncbi.nlm.nih.gov/articles/PMC6947274/pdf