Lamback, Elisa B.Henriques, Daniel G.Vazquez-Borrego, Mari C.de Azeredo Lima, Carlos H.Kasuki, LeandroLuque, Raul M.Chimelli, LeilaGadelha, Mônica R.2022-08-172022-08-172021Lamback EB, Henriques DG, Vazquez-Borrego MC, de Azeredo Lima CH, Kasuki L, Luque RM, et al. Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma. Arch Endocrinol Metab. 2021 Oct 29;65(5):648-6632359-3997http://hdl.handle.net/10668/3912Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/AcromegalyPituitary adenomaNeoplasias hipofisariasNeuroendocrine tumorsHyperplasiaGrowth hormone-releasing hormoneAcromegaliaTumores neuroendocrinosHiperplasiaHormona liberadora de hormona del crecimientoMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Persons::Persons::Age Groups::Adult::Young AdultMedical Subject Headings::Persons::Persons::Age Groups::AdultMedical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::AcromegalyMedical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary NeoplasmsMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neuroendocrine TumorsMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary Gland::Pituitary Gland, Anterior::SomatotrophsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::HyperplasiaMedical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary ApoplexyMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone-Releasing Hormones::Growth Hormone-Releasing HormoneMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance ImagingMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::RadiographyMedical Subject Headings::Anatomy::Respiratory System::Lungreview article34591404open access10.20945/2359-39970000003952359-4292