Frangou, SophiaModabbernia, AmirhosseinWilliams, Steven C RPapachristou, EfstathiosDoucet, Gaelle EAgartz, IngridAghajani, MojiAkudjedu, Theophilus NAlbajes-Eizagirre, AntonAlnaes, DagAlpert, Kathryn IAndersson, MicaelAndreasen, Nancy CAndreassen, Ole AAsherson, PhilipBanaschewski, TobiasBargallo, NuriaBaumeister, SarahBaur-Streubel, RamonaBertolino, AlessandroBonvino, AuroraBoomsma, Dorret IBorgwardt, StefanBourque, JosianeBrandeis, DanielBreier, AlanBrodaty, HenryBrouwer, Rachel MBuitelaar, Jan KBusatto, Geraldo FBuckner, Randy LCalhoun, VincentCanales-Rodríguez, Erick JCannon, Dara MCaseras, XavierCastellanos, Francisco XCervenka, SimonChaim-Avancini, Tiffany MChing, Christopher R KChubar, VictoriaClark, Vincent PConrod, PatriciaConzelmann, AnnetteCrespo-Facorro, BenedictoCrivello, FabriceCrone, Eveline ADale, Anders MDannlowski, UdoDavey, Christopherde Geus, Eco J Cde Haan, Lieuwede Zubicaray, Greig Iden Braber, AnoukDickie, Erin WDi Giorgio, AnnabellaDoan, Nhat TrungDørum, Erlend SEhrlich, StefanErk, SusanneEspeseth, ThomasFatouros-Bergman, HelenaFisher, Simon EFouche, Jean-PaulFranke, BarbaraFrodl, ThomasFuentes-Claramonte, PaolaGlahn, David CGotlib, Ian HGrabe, Hans-JörgenGrimm, OliverGroenewold, Nynke AGrotegerd, DominikGruber, OliverGruner, PatriciaGur, Rachel EGur, Ruben CHahn, TimHarrison, Ben JHartman, Catharine AHatton, Sean NHeinz, AndreasHeslenfeld, Dirk JHibar, Derrek PHickie, Ian BHo, Beng-ChoonHoekstra, Pieter JHohmann, SarahHolmes, Avram JHoogman, MartineHosten, NorbertHowells, Fleur MHulshoff Pol, Hilleke EHuyser, ChaimJahanshad, NedaJames, AnthonyJernigan, Terry LJiang, JiyangJönsson, Erik GJoska, John AKahn, ReneKalnin, AndrewKanai, RyotaKlein, MariekeKlyushnik, Tatyana PKoenders, LauraKoops, SanneKrämer, BerndKuntsi, JonnaLagopoulos, JimLázaro, LuisaLebedeva, IrinaLee, Won HeeLesch, Klaus-PeterLochner, ChristineMachielsen, Marise W JMaingault, SophieMartin, Nicholas GMartínez-Zalacaín, IgnacioMataix-Cols, DavidMazoyer, BernardMcDonald, ColmMcDonald, Brenna CMcIntosh, Andrew MMcMahon, Katie LMcPhilemy, GenevieveMeinert, SusanneMenchón, José MMedland, Sarah EMeyer-Lindenberg, AndreasNaaijen, JillyNajt, PabloNakao, TomohiroNordvik, Jan ENyberg, LarsOosterlaan, Jaapde la Foz, Víctor Ortiz-GarcíaPaloyelis, YannisPauli, PaulPergola, GiulioPomarol-Clotet, EdithPortella, Maria JPotkin, Steven GRadua, JoaquimReif, AndreasRinker, Daniel ARoffman, Joshua LRosa, Pedro G PSacchet, Matthew DSachdev, Perminder SSalvador, RaymondSánchez-Juan, PascualSarró, SalvadorSatterthwaite, Theodore DSaykin, Andrew JSerpa, Mauricio HSchmaal, LianneSchnell, KnutSchumann, GunterSim, KangSmoller, Jordan WSommer, IrisSoriano-Mas, CarlesStein, Dan JStrike, Lachlan TSwagerman, Suzanne CTamnes, Christian KTemmingh, Henk SThomopoulos, Sophia ITomyshev, Alexander STordesillas-Gutiérrez, DianaTrollor, Julian NTurner, Jessica AUhlmann, Annevan den Heuvel, Odile Avan den Meer, Dennisvan der Wee, Nic J Avan Haren, Neeltje E Mvan 't Ent, Dennisvan Erp, Theo G MVeer, Ilya MVeltman, Dick JVoineskos, AristotleVölzke, HenryWalter, HenrikWalton, EstherWang, LeiWang, YangWassink, Thomas HWeber, BerndWen, WeiWest, John DWestlye, Lars TWhalley, HeatherWierenga, Lara MWittfeld, KatharinaWolf, Daniel HWorker, AmandaWright, Margaret JYang, KunYoncheva, YulyiaZanetti, Marcus VZiegler, Georg CKarolinska Schizophrenia Project (KaSP)Thompson, Paul MDima, Danai2023-02-092023-02-092021-02-17http://hdl.handle.net/10668/17192Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/agingcortical thicknessdevelopmenttrajectoriesAdolescentAdultAgedAged, 80 and overCerebral CortexChildChild, PreschoolCross-Sectional StudiesFemaleHuman DevelopmentHumansMaleMiddle AgedNeuroimagingYoung Adultresearch article33595143open access10.1002/hbm.253641097-0193PMC8675431http://diposit.ub.edu/dspace/bitstream/2445/174673/1/hbm.25364.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675431/pdf