Pérez-Burillo, S.Hinojosa-Nogueira, D.Pastoriza, S.Rufián-Henares, J.A.2022-04-062022-04-062020-11Pérez-Burillo S, Hinojosa-Nogueira D, Pastoriza S, Rufián-Henares JA. Plant extracts as natural modulators of gut microbiota community structure and functionality. Heliyon. 2020 Nov 14;6(11):e05474.http://hdl.handle.net/10668/3527The main objective of this work was to evaluate the effect that several plant extracts (currently sold as functional ingredients) have on gut microbiota community structure and functionality. Plant extracts were submitted to an in vitro digestion and fecal fermentation. Overall, plant extracts showed a marked inhibitory activity when compared to basal conditions. However, they also favored the growth of some bacteria such as Coprococcus and Butyricimonas, two butyrate producers. Especially interesting was tea extract which inhibited the growth of the genus Escherichia/Shigella, known to involve species related with gastrointestinal disorders. Additionally, tea extract increased the growth of Faecalibacterium, a known butyrate producer. Regarding short chain fatty acids production, while plant extracts reduced acetate production, butyrate was increased for most samples, especially tea extract. Propionate production was less affected in comparison with basal conditions. Fermentation by gut microbiota also modified the antioxidant capacity (assessed via DPPH, FRAP and Folin-Ciocalteu methods).enAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Food scienceMicrobiologyPlant extractPhytochemicalsGut microbiotaShort chain fatty acidsAntioxidant capacityTeaTecnología de alimentosMicrobiologíaExtractos vegetalesFitoquímicosMicrobioma gastrointestinalÁcidos grasos volátilesCapacidad de absorbancia de radicales de oxígenoTéMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Food Industry::Food TechnologyMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::MicrobiologyMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Plant ExtractsMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::PhytochemicalsMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, VolatileMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Beverages::TeaMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism::FermentationMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Volatile::PropionatesMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::AntioxidantsMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Volatile::ButyratesMedical Subject Headings::Organisms::BacteriaMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Volatile::AcetatesMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseasesresearch article33251359Acceso abierto10.1016/j.heliyon.2020.e054742405-8440PMC7677688