Medrano, MayteCarrillo-Cruz, EstrellaMontero, IsabelPerez-Simon, Jose A2023-01-252023-01-252018-09-08http://hdl.handle.net/10668/12931Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called "non-classical actions." Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients' outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/allogeneic stem cell transplantationhaematopoiesisleukaemiamyelodysplastic syndromevitamin DAdaptive ImmunityAnimalsHematologic NeoplasmsHematopoiesisHumansImmunity, InnateLeukemiaMyelodysplastic SyndromesReceptors, CalcitriolStem Cell TransplantationVitamin DVitaminsresearch article30205552open access10.3390/ijms190926631422-0067PMC6164750https://www.mdpi.com/1422-0067/19/9/2663/pdf?version=1536386534https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164750/pdf