Barja-Fernández, SilviaFolgueira, CintiaCastelao, CeciliaPena-León, VerónicaGonzález-Saenz, PatriciaVázquez-Cobela, RocíoAguilera, Concepción MGil-Campos, MercedesBueno, GloriaGil, ÁngelMoreno, Luis ARuiz-Piñon, ManuelGarcía-Palacios, MaríaCasanueva, Felipe FDiéguez, CarlosNogueiras, RubénLeis, RosauraSeoane, Luisa M2023-01-252023-01-252019-06-14http://hdl.handle.net/10668/14128Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ANGPTL-4BMI losschildhoodlipid profileobesityAdolescentAngiopoietin-Like Protein 4Body Mass IndexChildChild, PreschoolCross-Sectional StudiesHumansIdeal Body WeightLipidsLongitudinal StudiesObesityresearch article31207920open access10.3390/nu110613402072-6643PMC6628529https://www.mdpi.com/2072-6643/11/6/1340/pdf?version=1560505448https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628529/pdf