Anguita-Ruiz, AugustoPlaza-Diaz, JulioRuiz-Ojeda, Francisco JavierRuperez, Azahara ILeis, RosauraBueno, GloriaGil-Campos, MercedesVazquez-Cobela, RocioCañete, RamonMoreno, Luis AGil, AngelAguilera, Concepcion Maria2023-01-252023-01-252019-05-24Anguita-Ruiz A, Plaza-Diaz J, Ruiz-Ojeda FJ, Rupérez AI, Leis R, Bueno G, et al. X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline. Sci Data. 2019 Jul 22;6(1):130.http://hdl.handle.net/10668/14281X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Genetic VariationChildChromosomes, Human, XFemaleGene FrequencyGenotypeHumansMaleOverweightPediatric ObesityPhenotypeSpainresearch article31332195open accessEspañaFenotipoGenotipoHumanosMasculinoObesidad infantilSobrepeso10.1038/s41597-019-0109-32052-4463PMC6646348https://www.nature.com/articles/s41597-019-0109-3.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646348/pdf