Perez-Carrasco, VirginiaSoriano-Lerma, AnaSoriano, MiguelGutiérrez-Fernández, JoséGarcia-Salcedo, Jose A.2022-09-192022-09-192021-05-18Perez-Carrasco V, Soriano-Lerma A, Soriano M, Gutiérrez-Fernández J, Garcia-Salcedo JA. Urinary Microbiome: Yin and Yang of the Urinary Tract. Front Cell Infect Microbiol. 2021 May 18;11:617002http://hdl.handle.net/10668/4064The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/MicrobiomeUrinary tractInfectionDiseaseHealthSequencingMicrobiotaSistema urinarioInfeccionesEnfermedadSaludDatos de secuencia molecularMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide SequencingMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaMedical Subject Headings::Anatomy::Urogenital System::Urinary TractMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Urinary Tract InfectionsMedical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Urinary BladderMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell ProliferationMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Ecosystem::Biodiversity::Biota::MicrobiotaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansreview article34084752open access10.3389/fcimb.2021.6170022235-2988PMC8167034