Alvarado Sánchez, Jorge IvánCaicedo Ruiz, Juan DanielDiaztagle Fernández, Juan JoseOspina Tascon, Gustavo AdolfoMonge Garcia, Manuel IgnacioRuiz Narvaez, Guillermo ArturoCruz Martínez, Luis Eduardo2023-05-032023-05-032022-02-16http://hdl.handle.net/10668/19587Several limitations regarding pulse pressure variation (PPV) use have been reported. Our aim was to describe changes in the PPV operative performance as a predictor of fluid responsiveness during the development of a swine endotoxin shock model and to assess hemodynamic variables associated with PPV changes. A swine porcine endotoxin shock model was established (Escherichia Coli 055:B5 endotoxin) in 7 pigs, and 3 pigs were included in the control group. The endotoxin was infused until the mean arterial pressure (MAP) dropped below 50 mmHg (TH0); then, the model animal was reanimated with fluids and vasopressors. We performed fluid challenges every hour for 6 h. ROC curve analysis and a linear mixed model were performed. The area under the curve of PPV decreased from 0.95 (0.81-1.00) to 0.60 (0.17-1.00) at TH0. Its cutoff increased from 10.5 to 22.00% at TH0. PPV showed an inverse relationship with stroke volume, mean systemic filling pressure, MAP, and systemic vascular resistance (SVR) (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AnimalsArterial PressureBlood PressureDisease Models, AnimalFemaleHemodynamicsROC CurveShock, SepticSwineVascular Resistanceresearch article35173214open access10.1038/s41598-022-06488-x2045-2322PMC8850593https://www.nature.com/articles/s41598-022-06488-x.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850593/pdf