Quesada-Gomez, Jose ManuelEntrenas-Castillo, MartaBouillon, Roger2023-02-092023-02-092020-06-07Quesada-Gomez JM, Entrenas-Castillo M, Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166. J Steroid Biochem Mol Biol. 2020 Sep;202:105719http://hdl.handle.net/10668/15734Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment. The major complication of coronavirus disease 2019 (COVID-19), the Acute Respiratory Distress syndrome (ARDS), is due to a variety of mechanisms including cytokine storm, dysregulation of the renin-angiotensin system, neutrophil activation and increased (micro)coagulation. Based on many preclinical studies and observational data in humans, ARDS may be aggravated by vitamin D deficiency and tapered down by activation of the vitamin D receptor. Several randomized clinical trials using either oral vitamin D or oral Calcifediol (25OHD) are ongoing. Based on a pilot study, oral calcifediol may be the most promising approach. These studies are expected to provide guidelines within a few months.en1α, 25(OH)2D or 1α, 25-dihydroxyvitamin D or calcitriolAcute respiratory distress syndrome (ARDS)Calcifediol or 25-hydroxyvitamin D3Corona virusCytokine stormHypercoagulabilityLung diseasesRenin-angiotensin systemSARS-CoV-2Vitamin D, vitamin D3 or cholecalciferolAdministration, oralBetacoronavirusCOVID-19CalcifediolCoronavirus infectionsHumansPandemicsPilot projectsPneumonia, viralRandomized controlled trials as topicRenin-angiotensin systemRespiratory distress syndromeSARS-CoV-2Vitamin DVitamin D deficiencyVitaminsresearch article32535032open accessAdministración oralDeficiencia de vitamina DInfecciones por CoronavirusNeumonía viralPandemiasProyectos pilotoSistema renina-angiotensinaSíndrome de dificultad respiratoriaVitamina D10.1016/j.jsbmb.2020.1057191879-1220PMC7289092https://doi.org/10.1016/j.jsbmb.2020.105719https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289092/pdf