Biezma, Maria IsabelMuñoz, PatriciaDe-la-Villa, SofiaFariñas-Alvarez, Mª CarmenArnaiz-de-Las-Revillas, FranciscoGutierrez-Carretero, EncarnacionDe-Alarcon, AristidesRodriguez-Garcia, RaquelLlopis, JaumeGoenaga, Miguel AngelGutierrez-Villanueva, AndreaPlata, AntonioVidal, LauraMartinez-Selles, Manuel2023-05-032023-05-032022-05-09Biezma MI, Muñoz P, De la Villa S, Fariñas-Álvarez MC, Arnáiz de Las Revillas F, Gutierrez-Carretero E, et al. Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences. J Clin Med. 2022 May 9;11(9):26512077-0383http://hdl.handle.net/10668/21284Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008−2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p< 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p <0.001) andone-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damagewasindependently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Diabetes mellitusIn-hospital mortalityInfective endocarditisOne-year mortalityOrgan damagePrognosisHospital MortalityPrevalenceRetrospective StudiesConfidence Intervalsresearch article35566777open accessEndocarditisDiabetes MellitusAnálisis MultivarianteSistema de RegistrosMortalidad Hospitalaria10.3390/jcm11092651PMC9103728https://www.mdpi.com/2077-0383/11/9/2651/pdf?version=1652064155https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103728/pdf