Alhambra-Exposito, Maria RIbañez-Costa, AlejandroMoreno-Moreno, PalomaRivero-Cortes, EstherVazquez-Borrego, Mari CBlanco-Acevedo, CristobalToledano-Delgado, AlvaroLombardo-Galera, Maria SVallejo-Casas, Juan AGahete, Manuel DCastaño, Justo PGalvez, Maria ALuque, Raul M2023-01-252023-01-252018-03-09Alhambra-Expósito MR, Ibáñez-Costa A, Moreno-Moreno P, Rivero-Cortés E, Vázquez-Borrego MC, Blanco-Acevedo C, et al. Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. Sci Rep. 2018 Apr 18;8(1):6173http://hdl.handle.net/10668/12367Acromegaly is a rare but severe disease, originated in 95% of cases by a growth hormone-secreting adenoma (somatotropinoma) in the pituitary. Magnetic resonance imaging (MRI) is a non-invasive technique used for the diagnosis and prognosis of pituitary tumours. The aim of this study was to determine whether the use of T2-weighted signal intensity at MRI could help to improve the characterisation of somatotropinomas, by analysing its relationship with clinical/molecular features. An observational study was implemented in a cohort of 22 patients (mean age = 42.1 ± 17.2 years; 59% women; 95% size>10 mm). Suprasellar-extended somatotropinomas presented larger diameters vs. non-extended tumours. T2-imaging revealed that 59% of tumours were hyperintense and 41% isointense adenomas, wherein hyperintense were more invasive (according to Knosp-score) than isointense adenomas. A higher proportion of hyperintense somatotropinomas presented extrasellar-growth, suprasellar-growth and invasion of the cavernous sinus compared to isointense adenomas. Interestingly, somatostatin receptor-3 and dopamine receptor-5 (DRD5) expression levels were associated with extrasellar and/or suprasellar extension. Additionally, DRD5 was also higher in hyperintense adenomas and its expression was directly correlated with Knosp-score and with tumour diameter. Hence, T2-weighted MRI on somatotropinomas represents a potential tool to refine their diagnosis and prognosis, and could support the election of preoperative treatment, when required.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AcromegalyBiomarkersDisease managementDisease susceptibilityGrowth hormone-secreting pituitary adenomaHumansMagnetic resonance imagingMaleMiddle agedNeoplasm gradingNeoplasm metastasisNeoplasm stagingRadiotherapyTreatment outcomeresearch article29670116open accessClasificación del tumorEstadificación de neoplasiasImagen por resonancia magnéticaMetástasis de la neoplasiaRadioterapiaResultado del tratamiento10.1038/s41598-018-24260-y2045-2322PMC5906631https://www.nature.com/articles/s41598-018-24260-y.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906631/pdf