Nieto, Francisco RafaelVuckovic, Sonja MaksimProstran, Milica S2023-02-092023-02-092020-09-16Nieto FR, Vuckovic SM, Prostran MS. Editorial: Mechanisms and New Targets for the Treatment of Chronic Pain. Front Pharmacol. 2020 Sep 29;11:600037. doi: 10.3389/fphar.2020.600037.1663-9812http://hdl.handle.net/10668/16497Nociceptive pain has a physiological protective role in preventing tissue injury. However, pain can become chronic due to a multitude of pathophysiological states, such as: inflammation, nerve injury, tumors, infections, autoimmune diseases, and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to painful hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes chronic, pathologic, and it can be extremely debilitating for people who suffer from it (Basbaum et al., 2009). Chronic pain has recently been defined as pain that persists or recurs for more than 3 months (Treede et al., 2019)enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/analgesicscancer-related painchronic painmusculoskeletal painneuropathic painpainpersistent painvisceral painChronic PainPeripheral Nervous System DiseasesNociceptive PainMetabolic DiseasesNeoplasmsInflammationresearch article33117184open accessDolor crónicoDolor nociceptivoEnfermedades metabólicasEnfermedades del sistema nervioso periféricoInflamaciónNeoplasias10.3389/fphar.2020.600037PMC7550778https://www.frontiersin.org/articles/10.3389/fphar.2020.600037/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550778/pdf