Frequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk.

Ferreira-Pêgo, CíntiaBabio, NancyBes-Rastrollo, MairaCorella, DoloresEstruch, RamonRos, EmilioFitó, MontserratSerra-Majem, LluísArós, FernandoFiol, MiguelSantos-Lozano, José ManuelMuñoz-Bravo, CarlosPintó, XavierRuiz-Canela, MiguelSalas-Salvadó, JordiPREDIMED Investigators2023-01-252023-01-252016-06-29http://hdl.handle.net/10668/10225The relation between the consumption of sweetened beverages and metabolic syndrome (MetS) is controversial. This analysis evaluated the associations between intakes of sugar-sweetened beverages (SSBs), artificially sweetened beverages, and natural and bottled fruit juices and the incidence of MetS in elderly individuals at high risk of cardiovascular disease (CVD) and without MetS at baseline. We prospectively examined 1868 participants free of MetS at baseline from the PREDIMED (PREvención con DIeta MEDiterránea) study. MetS was defined by using the updated harmonized criteria of the International Diabetes Federation, the American Heart Association, and National Heart, Lung, and Blood Institute. Energy and nutrient intakes were evaluated at baseline and then yearly by using a validated 137-item food-frequency questionnaire. Multivariable-adjusted HRs for MetS and its components were estimated from mean intakes during follow-up. We compared the 2 highest consumption categories (1-5 and >5 servings/wk) with the lowest category (5 servings/wk) with the lowest category ( A total of 930 incident cases of MetS were documented during a median follow-up of 3.24 y. When we compared consumption of >5 servings/wk with consumption of 5 servings/wk with consumption of The occasional consumption of SSBs and artificially sweetened beverages (1-5 servings/wk) was not associated with the incidence of MetS in middle-aged and elderly individuals at high risk of CVD. The consumption of >5 servings/wk of all of the types of beverages analyzed was associated with an increased risk of MetS and some of its components. However, for SSBs and bottled fruit juices these associations must be interpreted with caution because of the low frequency of consumption in this population. This trial was registered at clinicaltrials.gov as ISRCTN35739639.enPREDIMED studyartificially sweetened beveragesfruit juicesmetabolic syndromemetabolic syndrome componentssugar-sweetened beveragesAgedBeveragesCardiovascular DiseasesDietDiet SurveysDietary SucroseFeeding BehaviorFemaleFruit and Vegetable JuicesHumansIncidenceMaleMediterranean RegionMetabolic SyndromeMiddle AgedNon-Nutritive SweetenersProspective StudiesRisk FactorsSweetening AgentsFrequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk.research article27358413open access10.3945/jn.116.2303671541-6100https://academic.oup.com/jn/article-pdf/146/8/1528/29518599/jn230367.pdf