Jimenez-Martin, DeboraGarcia-Bocanegra, IgnacioRisalde, Maria AFernandez-Molera, VicenteJimenez-Ruiz, SaulIsla, JulioCano-Terriza, David2023-05-032023-05-032022-03-28Jiménez-Martín D, García-Bocanegra I, Risalde MA, Fernández-Molera V, Jiménez-Ruiz S, Isla J, et al. Epidemiology of paratuberculosis in sheep and goats in southern Spain. Prev Vet Med. 2022 May;202:105637http://hdl.handle.net/10668/22478Paratuberculosis is a worldwide, chronic infectious disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) that mainly affects ruminant species. This disease has a significant economic impact on small ruminant production due to the costs of implementing control measures and production losses. A cross-sectional study was carried out to determine the seroprevalence, spatial distribution and risk factors associated with MAP exposure in sheep and goats in Andalusia (southern Spain). Serum samples from 4134 small ruminants (2266 sheep and 1868 goats) in 153 flocks were tested by an in-house ELISA for antibodies against MAP using paratuberculosis protoplasmic antigen 3 (PPA3) as coating antigen. Antibodies against MAP were detected in 8.1% (183/2266; 95% CI: 7.0-9.2%) of sheep and 20.0% (374/1868; 95% CI: 18.2-21.8%) of goats. The true individual seroprevalence was 8.4% (95% CI: 6.9-10.1%) in sheep and 25.2% (95% CI: 22.7-27.8%) in goats. Seropositivity was detected in 66.3% (55/83; 95% CI: 56.1-76.4%) of sheep herds and 90.0% (63/70; 95% CI: 83.0-97.0%) of goat herds. Spatial analysis identified three statistically significant clusters (p enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Animal healthMycobacterium aviumParatuberculosisRisk-basedSeroprevalenceSmall ruminantsSurveillanceAnimalsCross-sectional studiesGoat diseasesGoatsMycobacterium avium subsp. paratuberculosisParatuberculosisRuminantsSeroepidemiologic studiesSheepSheep diseasesSpainresearch article35378433open accessCabrasEnfermedades de las cabrasEnfermedades de las ovejasEspañaEstudios seroepidemiológicosEstudios transversalesOvinosParatuberculosisRumiantes10.1016/j.prevetmed.2022.1056371873-1716https://doi.org/10.1016/j.prevetmed.2022.105637