Brana, Alfredo F.Sarmiento-Vizcaino, AidaOsset, MiguelPerez-Victoria, IgnacioMartin, Jesusde Pedro, Nuriade la Cruz, MercedesDiaz, CaridadVicente, FranciscaReyes, FernandoGarcia, Luis A.Blanco, Gloria2023-02-122023-02-122017-05-01http://hdl.handle.net/10668/19298The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/lobophorinsspirotetronate antibioticStreptomycesantitumorCantabrian Sea-derived actinobacteriaSpirotetronate antibioticsMetabolitesresearch articleopen access10.3390/md150501441660-3397https://www.mdpi.com/1660-3397/15/5/144/pdf404235100020