Salas Buzon, Maria del CarmenGutierrez Bayard, LuciaRodriguez Sanchez, RaquelQuinones Rodriguez, Luis AngelSayago Gil, SarahMunoz Higueras, Cristina2025-01-072025-01-072021-01-011689-832Xhttps://hdl.handle.net/10668/25225Purpose: The aim of this prospective study was to analyze dosimetric impact of modifying bladder filling on dose distribution in organs at risk (OARs) when using contrast in the small bowel of patients under adjuvant therapy with high-dose-rate vaginal cuff brachytherapy (HDR-VCB) for endometrial cancer.Material and methods: This research included 19 patients who underwent laparoscopic surgery. They were treated with HDR-VCB and 2.5-3.5 cm diameter cylinders. Two successive computerized tomography (CT) scans were performed, with empty bladder and with bladder filled with 180 cc of saline solution. Bladder, rectum, sigmoid, and small bowel were delineated as OARs. Oral barium contrast was used to clearly visualize small bowel loops. Prescription dose was 7 Gy. Dose-volume histograms were generated for each OAR, with full and empty bladder to compare doses received.Results: Bladder distension had no dosimetric impact on the bladder, rectum, or sigmoid, unlike the small bowel. With full bladder, mean minimum dose at 2 cc (D-2cc) was not significantly higher for full vs. empty bladder (5.56 vs. 5.06 Gy, p = 0.07), whereas there was a significant reduction in the small bowel (1.68 vs. 2.70 Gy, penAttribution-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-sa/4.0/endometrial cancervaginal cuff brachytherapysmall bowelbladder distentionbariumHigh-dose-rateAmerican brachytherapyEndometrial cancer3-dimensional dosimetryVault brachytherapyGuidelinesCarcinomaresearch article35079252open access10.5114/jcb.2021.1121172081-2841https://www.termedia.pl/Journal/-54/pdf-45972-10?filename=Dosimetric impact.pdf738217800006