Stratigos, Alexander JGarbe, ClausDessinioti, ClioLebbe, CelesteBataille, VeroniqueBastholt, LarsDreno, BrigitteFargnoli, Maria ConcettaForsea, Ana MariaFrenard, CecilleHarwood, Catherine ΑHauschild, AxelHoeller, ChristophKandolf-Sekulovic, LidijaKaufmann, RKelleners-Smeets, Nicole WjMalvehy, JosepDel Marmol, VeroniqueMiddleton, Mark RMoreno-Ramirez, DavidPellecani, GiovanniPeris, KettySaiag, Philippevan den Beuken-van Everdingen, Marieke H JVieira, RicardoZalaudek, IrisEggermont, Alexander M MGrob, Jean-JacquesEuropean Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)2023-02-082023-02-082020-02-26http://hdl.handle.net/10668/15183Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation of Research and Treatment of Cancer (EORTC) was formed to update recommendations on cSCC classification, diagnosis, risk stratification, staging and prevention, based on current literature, staging systems and expert consensus. Common cSCCs are typically indolent tumors, and most have a good prognosis with 5-year cure rates of greater than 90%, and a low rate of metastases (enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DiagnosisHigh-risk common primary cSCCImagingInvasive cutaneous squamous cell carcinomaLocally advanced CsccLow-riskMetastatic cSCCPreventionPrognosisStagingCarcinoma, Squamous CellConsensusDermatologyHumansLymph NodesMagnetic Resonance ImagingMedical OncologyNeoplasm StagingPatient Education as TopicPositron Emission Tomography Computed TomographyProtective ClothingRisk AssessmentSkinSkin NeoplasmsSocieties, MedicalSunlightSunscreening AgentsUltrasonographyresearch article32113941open access10.1016/j.ejca.2020.01.0071879-0852https://arts.units.it/bitstream/11368/2966368/4/11368_2966368_print.pdf