Miravitlles, MarcSoler-Cataluña, Juan JoséSoriano, Joan BGarcía-Río, Franciscode Lucas, PilarAlfageme, InmaculadaCasanova, CiroRodríguez González-Moro, José MiguelSánchez-Herrero, M GuadalupeAncochea, JulioCosío, Borja G2023-05-032023-05-032022-03-05http://hdl.handle.net/10668/20313Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil count (BEC) in individuals with and without COPD. EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general population, and COPD was defined by a post-bronchodilator FEV1/FVC  A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard deviation [SD]) was 63.2 years (11.0), 46.3% were male, and 27.6% were active smokers. BEC was significantly higher in individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p = 0.0003]. In a stepwise multivariate model, being male, active smoker and having a previous diagnosis of asthma were independently associated with having a higher BEC. This population-based study estimated the distribution of eosinophils in the healthy adult population and concluded that COPD patients have a significantly higher BEC. Male sex, active smoking and concomitant asthma were significantly associated with a higher BEC.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/BiomarkersComputed tomographyEpidemiologyImaging populationAgedBiomarkersCross-Sectional StudiesEosinophiliaEosinophilsFemaleForced Expiratory VolumeHumansMaleMiddle AgedMorbidityPopulation SurveillancePulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSpainresearch article35248041open access10.1186/s12931-022-01965-31465-993XPMC8897916https://doi.org/10.1186/s12931-022-01965-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897916/pdf