Lopez-Lopez, PedroFrias, MarioCamacho, AngelaMachuca, IsabelCaballero-Gomez, JavierRisalde, Maria AGarcia-Bocanegra, IgnacioPerez-Valero, IgnacioGomez-Villamandos, Jose CRivero-Juarez, AntonioRivero, Antonio2023-05-032023-05-032022-02-17López-López P, Frias M, Camacho A, Machuca I, Caballero-Gómez J, Risalde MA, et al. Seroreversion of IgG anti-HEV in HIV cirrhotic patients: A long-term multi-sampling longitudinal study. Transbound Emerg Dis. 2022 Sep;69(5):e1541-e1548http://hdl.handle.net/10668/20022The aim of our study was to evaluate HEV antibody kinetics in HIV/HCV-coinfected patients with cirrhosis. A longitudinal retrospective study was designed. Patients were followed up every 6 months; anti-HEV IgG and IgM antibodies levels and HEV-RNA by qPCR were analysed. The prevalence and incidence of every HEV infection marker were calculated. The kinetics of anti-HEV IgG and IgM during the follow-up were evaluated. Seventy-five patients comprised the study population. The seroprevalence observed was 17.3%. None showed IgM antibodies or HEV-RNA at baseline. None showed detectable HEV viral load during the study period. After a median follow-up of 5.1 years, two of 62 seronegative patients (3.2%) seroconverted to IgG antibody. The incidence for IgM was 2.7%. Of the 13 patients with IgG seropositivity at baseline, five (38.5%) seroreverted. Meanwhile, of the two patients who exhibited IgM positivity during the study, one (50%) showed intermittent positivity. We found that HEV seropositivity is common in HIV/HCV-coinfected cirrhotic patients. A remarkable rate of IgG seroreversions and IgM intermittence was found, limiting the use of antibodies for the diagnosis of HEV infection in this population.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HCVHEVHIVAntibodiesCirrhoticSeroreversionAnimalsHIV infectionsHepatitis antibodiesHepatitis CHepatitis E virusImmunoglobulin GImmunoglobulin MLiver cirrhosisLongitudinal studiesRNA, viralRetrospective studiesSeroepidemiologic studiesresearch article35184415open accessARN viralAnticuerpos antihepatitisCirrosis hepáticaEstudios seroepidemiológicosInfecciones por VIHInmunoglobulina GInmunoglobulina MVirus de la Hepatitis E10.1111/tbed.144861865-1682PMC9790577http://helvia.uco.es/xmlui/bitstream/10396/22948/1/seroreversion_of_igG_anti_hev_in_hiv_cirrhotic_patients.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790577/pdf