Sánchez-Encinales, VivianaÁlvarez-Marín, RocíoPachón-Ibáñez, María EugeniaFernández-Cuenca, FelipePascual, AlvaroGarnacho-Montero, JoséMartínez-Martínez, LuisVila, JordiTomás, María MarCisneros, José MiguelBou, GermánRodríguez-Baño, JesúsPachón, JerónimoSmani, Younes2023-01-252023-01-252017http://hdl.handle.net/10668/11147Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort. Representative isolates were classified into 2 groups: (1) isolates from patients colonized by A. baumannii (16 from the unicenter and 20 from the multicenter cohort) and (2) isolates from bacteremic or nonbacteremic patients with pneumonia (PP) caused by A. baumannii (13 from the unicenter and 23 from the multicenter cohort) Expression of ompA was determined with quantitative reverse-transcription polymerase chain reaction. Isolates from PP overexpressed more ompA than those from colonized patients from the unicenter (ratio, 1.76 vs 0.36; P These data suggest that ompA overexpression is an associated factor for pneumonia, bacteremia, and death due to A. baumannii.enAcinetobacter baumanniibacteremiamortalitypneumoniaOmpAAcinetobacter baumanniiAdolescentAdultAgedAged, 80 and overAnimalsBacteremiaBacterial Outer Membrane ProteinsCross InfectionDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisPneumonia, BacterialRisk FactorsSepsisSeverity of Illness IndexYoung Adultresearch article28453834open access10.1093/infdis/jix0101537-6613https://academic.oup.com/jid/article-pdf/215/6/966/13923889/jix010.pdf