Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

Rogati, FedericaMillán, EstrellaAppendino, GiovanniCorrea, AlejandroCaprioglio, DiegoMinassi, AlbertoMuñoz, Eduardo2025-01-072025-01-072019-01-081948-5875https://hdl.handle.net/10668/28272The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.enIdentification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.research article30996804open access10.1021/acsmedchemlett.8b00604PMC6467025https://europepmc.org/articles/pmc6467025?pdf=renderhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6467025/pdf