Navarrete-Muñoz, Eva-MariaVioque, JesusToledo, EstefaníaOncina-Canovas, AlejandoMartínez-González, Miguel ÁngelSalas-Salvadó, JordiCorella, DoloresFitó, MontserratRomaguera, DoraAlonso-Gómez, Ángel MWärnberg, JuliaMartínez, J AlfredoSerra-Majem, LuísEstruch, RamonTinahones, Francisco JLapetra, JoséPintó, XavierTur, Josep ALópez-Miranda, JoséBueno-Cavanillas, AuroraMatía-Martín, PilarDaimiel, LidiaSánchez, Vicente MartínVidal, Josepde Cos Blanco, Ana IsabelRos, EmiliDiez-Espino, JavierBabio, NancyFernandez-Carrion, RebecaCastañer, OlgaColom, AntoniCompañ-Gabucio, LauraLete, Itziar SalaverriaCrespo-Oliva, EdelysAbete, ItziarTomaino, LauraCasas, RosaFernandez-Garcia, José CarlosSantos-Lozano, José ManuelSarasa, IziarGámez, José MGarcia-Rios, José M AntonioMartín-Pelaez, SandraRuiz-Canela, MiguelDíaz-López, AndrésMartinez-Lacruz, RaulZomeño, Maria DolorsRayó, ElenaSellés, Cristina GisbertCanudas, SilviaGoday, AlbertGarcía-de-la-Hera, Manoli2023-02-092023-02-092020-08-24http://hdl.handle.net/10668/16141We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.enCardiometabolic riskCholesterolDiabetesFolateMetabolic syndrome scoreAgedBody Mass IndexCross-Sectional StudiesFolic AcidHumansMetabolic SyndromeObesityRisk Factorsresearch article32833162open access10.1007/s00394-020-02364-41436-6215http://repositori.upf.edu/bitstream/10230/48455/1/Navarrete_ejn_diet.pdf