Soler Garcia, A.Padilla Parrado, F.Figueroa-Ortiz, L. C.Gonzalez Gomez, A.Garcia-Ben, A.Garcia-Ben, E.Garcia-Campos, J. M.2023-02-122023-02-122016-07-010213-4853http://hdl.handle.net/10668/18850Introduction: Quantitative assessment of macular and nerve fibre layer thickness in multiple sclerosis patients with regard to expanded disability status scale (EDSS) and presence or absence of previous optic neuritis episodes.Methods: We recruited 62 patients with multiple sclerosis (53 relapsing-remitting and 9 secondary progressive) and 12 disease-free controls. All patients underwent an ophthalmological examination, including quantitative analysis of the nerve fibre layer and macular thickness using optical coherence tomography. Patients were classified according to EDSS as A (lower than 1.5), B (between 1.5 and 3.5), and C (above 3.5).Results: Mean nerve fibre layer thickness in control, A, B, and C groups was 103.35 +/- 12.62, 99.04 +/- 14.35, 93.59 +/- 15.41, and 87.36 +/- 18.75 mu m respectively, with statistically significant differences (PesMacular thicknessNerve fibre layerMultiple sclerosisExpanded disability status scaleOptic neuritisCoherence tomographyBrain atrophyDisabilityAnalysis of macular and nerve fiber layer thickness in multiple sclerosis patients according to severity level and optic neuritis episodesresearch articleopen access10.1016/j.nrl.2014.09.0031578-1968https://doi.org/10.1016/j.nrl.2014.09.003380180000003