Fernandez-Garcia, Jose CarlosBarrios-Rodriguez, RocioAsenjo-Plaza, MaiteRamos-Molina, BrunoMolina-Vega, MariaGuzman-Guzman, AntonioMoreno-Leon, LuisYubero-Serrano, Elena MRius-Diaz, FranciscaValdes, SergioMartinez-Gonzalez, Miguel AngelJimenez-Moleon, Jose JuanTinahones, Francisco J2023-05-032023-05-032022-08-11Fernández-García JC, Barrios-Rodríguez R, Asenjo-Plaza M, Ramos-Molina B, Molina-Vega M, Guzmán-Guzmán A, et al. Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial. Metabolism. 2022 Nov;136:155290http://hdl.handle.net/10668/22390Men with obesity tend to be insulin resistant and often have low-normal testosterone concentrations. We conducted a clinical trial aimed to evaluate potential therapeutic strategies for low testosterone in men with obesity. We did a 1-year, parallel, randomized, double-blind, placebo-controlled trial, where we evaluated the independent and combined effects of metformin and testosterone in 106 men with obesity, aged 18-50 years, who had low levels of testosterone and no diabetes mellitus. The primary outcome was change in insulin resistance, measured as Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) index. Secondary outcomes included changes in total and free serum testosterone, body composition, metabolic variables, erectile function, and health-related quality of life (HRQoL). In the intention-to-treat analysis, the HOMA-IR index decreased significantly in all active groups compared to placebo (metformin -2.4, 95 % CI -4.1 to -0.8, p = 0.004; testosterone -2.7, 95 % CI -4.3 to -1.1, p = 0.001; combination -3.4, 95 % CI -5.0 to -1.8, p  Among men with obesity and low testosterone concentrations, the combination of metformin plus testosterone, metformin only, and testosterone only, compared to placebo, reduced insulin resistance with no evidence of additive benefit.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Erectile dysfunctionInsulin resistanceMetforminObesityTestosteroneDouble-blind methodErectile dysfunctionHumansHypoglycemic agentsInsulinInsulin resistanceMaleMetforminObesityQuality of lifeTestosteroneresearch article35985506open accessCalidad de vidaDisfunción eréctilHipoglucemiantesInsulinaMetforminaMétodo doble ciegoObesidadResistencia a la iInsulinaTestosterona10.1016/j.metabol.2022.1552901532-8600http://www.metabolismjournal.com/article/S0026049522001688/pdf