Ruano-Ravina, AlbertoProvencio, MarianoCalvo de Juan, VirginiaCarcereny, EnricEstival, AnnaRodríguez-Abreu, DelvysBenítez, GretelLópez-Castro, RafaelBelver, MartaGuirado-Risueño, MaríaGuirao-Rubio, CarlosBlasco, AnaMassutí, BartomeuOrtega, Ana LauraCobo, ManuelMosquera-Martínez, JoaquínAguado de la Rosa, CarlosBosch-Barrera, JoaquimSánchez-Gastaldo, AmparoDel Barco Morillo, EdelJuan, ÓscarDómine, ManuelTrigo, José ManuelPereiro Corbacho, DiegoOramas, Juana2022-09-082022-09-082021-10Ruano-Ravina A, Provencio M, Calvo de Juan V, Carcereny E, Estival A, Rodríguez-Abreu D, et al. Are there differences by sex in lung cancer characteristics at diagnosis? -a nationwide study. Transl Lung Cancer Res. 2021 Oct;10(10):3902-39112218-6751http://hdl.handle.net/10668/4017Background: Lung cancer causes approximately 25% of all cancer deaths. Despite its relevance, few studies have analyzed differences by sex at the time of diagnosis in terms of symptoms, stage, age or smoking status. We aim to assess if there are differences between men and women on these characteristics at diagnosis. Methods: We analyzed the Thoracic Tumour Registry (TTR), sponsored by the Spanish Lung Cancer Group using a case-series design. This is a nationwide registry of lung cancer cases which started recruitment in 2016. For each case included, clinicians fulfilled an electronic record registering demographic data, symptoms, exposure to lung cancer risk factors, and treatment received in detail. We compared men and women using descriptive statistics. Results: A total of 13,590 participants took part in this study, 25.6% women. Women were 4 years younger than men (64 vs. 69), and men had smoked more frequently. Adenocarcinoma was the most frequent histological type in both sexes. Stage IV at diagnosis was 50.8% in women compared to 43.6% in men. Weight loss/anorexia/asthenia was the most frequent symptom in both sexes and there were no differences in the number of symptoms at diagnosis. There were no relevant differences in the frequency or number of symptoms by sex when non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) were analyzed separately. Smoking status did not appear to cause different lung cancer presentation in men compared to women.10 p.enAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Lung neoplasmsSexSymptomsSmokingSmall cell lung cancer (SCLC)Neoplasias pulmonaresSexoSíntomasFumarCarcinoma pulmonar de células pequeñasAnorexiaAstheniaAsteniaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell LungMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung NeoplasmsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Digestive::AnorexiaMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::AstheniaMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::AdenocarcinomaMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::SmokingMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::RegistriesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight LossMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::DemographyMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Physics::Electronicsresearch article34858780open access10.21037/tlcr-21-5592226-4477PMC8577975