Linares-Pineda, Teresa MariaBoughanem, HatimGutierrez-Repiso, CarolinaMacias-Gonzalez, ManuelAndres-Leon, EduardoRojo-Martinez, GemmaValdes, SergioTinahones, Francisco JMorcillo, Sonsoles2023-05-032023-05-032022-07-12Linares-Pineda TM, Boughanem H, Gutiérrez-Repiso C, Macías-González M, Andrés-León E, Rojo-Martínez G, et al. Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study. Eur J Clin Invest. 2022 Aug;52(8):e13783http://hdl.handle.net/10668/19947Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. Accordingly, long- term obesity is involved in an increased risk of developing several metabolic diseases, such as cardiovascular diseases, insulin resistance or type 2 diabetes. Although it is common to find obesity- related disorders in the majority of individuals with obesity, some of them do not show metabolic complications.1 Obese people without these metabolic disorders are defined as metabolically healthy obesity (MHO) individuals, whereas those who present metabolic complications are known as metabolically unhealthy obesity (MUO) subjects.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Insulin ResistanceObesity, Metabolically BenignDiabetes Mellitus, Type 2Cardiovascular DiseasesGlobal HealthBody Mass IndexCase-Control StudiesEpigenesis, GeneticHumansMetabolic SyndromeObesityObesity, Metabolically BenignProspective StudiesRisk Factorsresearch article35342930open accessDiabetes Mellitus Tipo 2Enfermedades MetabólicasEstadísticaEnfermedades CardiovascularesResistencia a la InsulinaObesidad Metabólica Benigna10.1111/eci.137831365-2362PMC9539510https://riuma.uma.es/xmlui/bitstream/10630/24638/1/Eur%20J%20Clin%20Investigation%20-%202022%20-%20Linares%e2%80%90Pineda%20-%20Epigenetic%20changes%20in%20the%20metabolically%20healthy%20obese%20%20A%20case%e2%80%90control.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539510/pdf