García-Costela, MaríaEscudero-Feliú, JuliaPuentes-Pardo, Jose D.San Juán, Sara MorenoMorales-Santana, SoniaRíos-Arrabal, SandraCarazo, ÁngelLeón, Josefa2022-03-302022-03-302020-09-11García-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, et al. Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front Endocrinol (Lausanne). 2020 Sep 11;11:638http://hdl.handle.net/10668/3502Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Pancreatic cancerCircadian clockChemotherapyMetabolismPrecision medicineNeoplasias pancreáticasRelojes circadianosDrug therapyMetabolismoMedicina de precisiónMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::ApoptosisMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell ProliferationMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Biological Clocks::Circadian ClocksMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian RhythmMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease ProgressionMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Chemotherapy, AdjuvantMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolismreview article33042011open access10.3389/fendo.2020.006381664-2392PMC7516350