Delgado Torralbo, ElenaVazquez Moreno, Julio AGarcía León, JavierGonzález Enríquez, JesúsMartínez Navarro, FerránBerrón Morato, SonsolesMayoral Cortés, José MaríaRubin Gómez, M ÁngelesMéndez Martínez, CamilaCortés Majó, MargaritaChaves Caballero, MónicaBernal González, Mª Luisa2015-07-072015-07-072000-07Delgado Torralbo E, Vazquez Moreno JA, García León J, González Enríquez J, Martínez Navarro F, Berrón Morato S, et al. Niveles de anticuerpos bactericidas frente a meningococo C tras la vacunación de niños de 2 a 6 años de edad en Andalucía. Rev. Esp. Salud Publica; 74(4):433-441135-5727http://hdl.handle.net/10668/1921Estudio especial; English Abstract; Journal Article;BACKGROUND In 1997, 18.5% of the cases of Meningococcal Disease caused b serogroup C in Andalusia were children between 2 and 4 years of age; ages where the initial immune response and the duration of the capsular A + C meningococcal polysaccharide vaccine is less than in older age groups. Research was designed in order to measure the immune response produced by this vaccine in children from 2 to 6 years of age and to compare it with the natural immunity present in unvaccinated children. METHODS I. Dual monitoring study: a) groups of children vaccinated previously and control groups, b) groups of children who were going to be vaccinated, for pre and post-vaccination (1, 6 and 12 months) analysis and a control group. II. The bactericidal activity was measured according to the standardised protocol of the CDC with regard to the strain of N. meningitidis C-11. The sera with bactericidal activity (TAB) > 1:8 were considered to be protective. RESULTS 1 and 2 months following vaccination, the proportion of TAB > 1:8 was significantly higher than that of the control group (65.6% and 73% in comparison to 2.2% and 12%). In the pre-vaccine and post-vaccine (after 6, 7, 12 and 13 months) verification, no significant difference between vaccinated individuals and controls was observed. CONCLUSIONS The differences between vaccinated and unvaccinated individuals 1 and 2 months following vaccination indicate seroconversion in the vaccinated individuals. For the age group of between 2 to 6 years of age, the bactericidal activity acquired decline quickly, as, after 6 months, differences between this group and the control group are no longer observed.Fundamento: En 1997 el 18,5% de los casos de Enfermedad Meningccócica por serogrupo C en Andalucía fueron niños de 2 a 4 años de edad; edades donde respuesta inmune inicial y duración de la vacuna antimeningocócica de polisactido capsular A+C, es menor que en edades superiores. Se diseñó una investigación para medir la respuesta inmune producida por esta vacuna, en niños de 2 a 6 años de edad, y compararla con la inmunidad natural presente en milos no vacunados. Métodos: 1. Doble estudio de seguimiento: J) grupos de niños previamente vacunados y grupos control, b) grupo de niños que iba a ser vacunado, para análisis pre y postvacunal(l.6 y 12 meses) y grupo control. II.- La actividad bactericida se midió según protocolo estandarizado del CDC frente a cepa de N. rnehyírih C-11. Los sueros con título de actividad bactericida (TAB)> 1.8 se consideraron protectores. Resultados: Al mes y a los 2 meses de vacunarse la proporción de TAB>I:B era significativamente superior a la del grupo control (65.5% y 73,9% frente a 2,2% y 12%). En el prevacunal y en el postvacunal a los 6. 7, 12 y 13 meses no se observó diferencia significativa entre vacunados y controles. Conclusiones: Las diferencias entre vacunados y no vacunados 1 y 2 meses después de la vacunación indican seroconversión en los vacunados. Para el grupo de edad de 2 a 6 años la actividad bactericida adquirida declina rápidamente, ya que a los 6 meses dejan de observarse diferencias con el grupo control.spaEnfermedad meningocócicaVacuna antimeningocócicaMeningococcal VaccinesAntibodies, BacterialMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control StudiesMedical Subject Headings::Named Groups::Persons::Age Groups::ChildMedical Subject Headings::Named Groups::Persons::Age Groups::Child::Child, PreschoolMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Agents::Vaccines::Bacterial Vaccines::Meningococcal VaccinesMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Neisseriaceae::Neisseria::Neisseria meningitidisMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Bacterialresearch article11031854open access2173-9110