Verge González, CarmenLucena González, María IsabelLópez-Torres, EnriquePuche-García, María JoséFraga, EnriqueRomero-Gómez, ManuelAndrade Bellido, Raúl Jesús2013-03-112013-03-112006-08-21Verge González C, Lucena González MI, López-Torres E, Puche-García MJ, Fraga E, Romero-Gómez M, et al. Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs? World J. Gastroenterol.. 2006;12(31):5078-801007-9327http://hdl.handle.net/10668/815Case Reports; Journal Article; Research Support, Non-U.S. Gov't;Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.enCalcium carbimideHepatotoxicityDisuasivos de AlcoholCianamidaDisulfiramInteracciones de DrogasHígadoEnfermedad Hepática Inducida por DrogasFemeninoHumanosMasculinoMediana EdadAdultoMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Alcohol DeterrentsMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Hydrogen Cyanide::Cyanides::CyanamideMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates::Thiocarbamates::Ditiocarb::DisulfiramMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug InteractionsMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver InjuryMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Anatomy::Digestive System::LiverMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article16937512open access2219-2840