Salazar de Pablo, GonzaloGuinart, DanielCornblatt, Barbara AAuther, Andrea MCarrión, Ricardo ECarbon, MarenJiménez-Fernández, SaraVernal, Ditte LWalitza, SusanneGerstenberg, MiriamSaba, RiccardoLo Cascio, NellaBrandizzi, MartinaArango, CelsoMoreno, CarmenVan Meter, AnnaCorrell, Christoph U2023-02-082023-02-082020-02-21http://hdl.handle.net/10668/15142Objectives: Bipolar disorder (BD) is a debilitating illness that often starts at an early age. Prevention of first and subsequent mood episodes, which are usually preceded by a period characterized by subthreshold symptoms is important. We compared demographic and clinical characteristics including severity and duration of subsyndromal symptoms across adolescents with three different bipolar-spectrum disorders. Methods: Syndromal and subsyndromal psychopathology were assessed in adolescent inpatients (age = 12-18 years) with a clinical mood disorder diagnosis. Assessments included the validated Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P). We compared phenomenology across patients with a research consensus conference-confirmed DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) diagnoses of BD-I, BD-not otherwise specified (NOS), or mood disorder (MD) NOS. Results: Seventy-six adolescents (age = 15.6 ± 1.4 years, females = 59.2%) were included (BD-I = 24; BD-NOS = 29; MD-NOS = 23) in this study. Median baseline global assessment of functioning scale score was 21 (interquartile range = 17-40; between-group p = 0.31). Comorbidity was frequent, and similar across groups, including disruptive behavior disorders (55.5%, p = 0.27), anxiety disorders (40.8%, p = 0.98), and personality disorder traits (25.0%, p = 0.21). Mania symptoms (most frequent: irritability = 93.4%, p = 0.82) and depressive symptoms (most frequent: depressed mood = 81.6%, p = 0.14) were common in all three BD-spectrum groups. Manic and depressive symptoms were more severe in both BD-I and BD-NOS versus MD-NOS (p enadolescencebipolar disorderpreventionrisksubsyndromalAdolescentAnxiety DisordersAttention Deficit and Disruptive Behavior DisordersBipolar DisorderChildDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMood DisordersPersonality DisordersPsychotropic DrugsSeverity of Illness Indexresearch article32083495open access10.1089/cap.2019.01381557-8992PMC7232658https://europepmc.org/articles/pmc7232658?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232658/pdf