Camarillo, RosaJimeno, SoniaHuertas, Pablo2025-01-072025-01-072021-10-081664-8021https://hdl.handle.net/10668/28366The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DNA double strand break repairDNA end resectionG-quadruplexR-loopshomologous recombination (HR)research article34691154open access10.3389/fgene.2021.742434PMC8531813https://www.frontiersin.org/articles/10.3389/fgene.2021.742434/pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8531813/pdf