Huertas, IsmaelJesús, SilviaLojo, José AntonioGarcía-Gómez, Francisco JavierCáceres-Redondo, María TeresaOropesa-Ruiz, Juan ManuelCarrillo, FátimaVargas-Gonzalez, LauraMartín Rodríguez, Juan FranciscoGómez-Garre, PilarGarcía-Solís, DavidMir, Pablo2023-01-252023-01-252017-03-30http://hdl.handle.net/10668/11023Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability. We included 75 PD patients from whom we collected information about their motor symptoms, DAT imaging and UA concentration levels. Based on the predominance of their motor symptoms, patients were classified into postural instability and gait disorder (PIGD, n = 36), intermediate (I, n = 22), and tremor-dominant (TD, n = 17) subtypes. The levels of UA and striatal DAT were compared across subtypes and the correlation between these two measures was also explored. We found that PIGD patients had lower levels of UA (3.7 vs 4.5 vs 5.3 mg/dL; PenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsFemaleGaitHumansMaleMiddle AgedMolecular ImagingNeuropsychological TestsParkinson DiseasePostural BalanceUric Acidresearch article28358829open access10.1371/journal.pone.01746441932-6203PMC5373593https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0174644&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373593/pdf