Pérez-Ramírez, CristinaCañadas-Garre, MarisaAlnatsha, AhmedVillar, EduardoDelgado, Juan RamónCalleja-Hernández, Miguel ÁngelFaus-Dáder, María José2023-01-252023-01-252017-11-21http://hdl.handle.net/10668/11924Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/DNA repair pathwayFolate metabolism pathwayGlutathione metabolism pathwayNon-small cell lung cancerPolymorphismsRiskAgedAged, 80 and overCarcinoma, Non-Small-Cell LungDNA DamageDNA RepairFemaleGenotypeGlutathioneHumansLung NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideRiskresearch article29254785open access10.1016/j.prp.2017.11.0151618-0631https://pureadmin.qub.ac.uk/ws/files/138222058/1_s2.0_S0344033817308956_main.pdf