Soriano-Maldonado, AlbertoDíez-Fernández, David MEsteban-Simón, AlbaRodríguez-Pérez, Manuel AArtés-Rodríguez, EvaCasimiro-Artés, Miguel AMoreno-Martos, HerminiaToro-de-Federico, AntonioHachem-Salas, NurBartholdy, CecilieHenriksen, MariusCasimiro-Andújar, Antonio J2023-05-032023-05-032022-03-22http://hdl.handle.net/10668/20919This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors. A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction. Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361-1.074, P  and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve. ISRCTN14601208.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Breast cancerCancer-related fatigueHealth-related quality of lifeMuscular strengthResistance trainingresearch article35314958open access10.1007/s11764-022-01192-11932-2267https://link.springer.com/content/pdf/10.1007/s11764-022-01192-1.pdf