Nogueras-Morillas, PalomaBlasco-Morente, GonzaloEspadafor-López, BeatrizAneiros-Fernández, JoséTercedor-Sánchez, Jesús2016-05-172016-05-172016-03-01Nogueras-Morillas P, Blasco-Morente G, Espadafor-López B, Aneiros-Fernández J, Tercedor-Sánchez J. Keratotic Nodule on The Heel: A Quiz. Acta Derm. Venereol. 2016; 96(3):427-4310001-5555http://hdl.handle.net/10668/2193JOURNAL ARTICLE;A 51-year-old man, with a medical history of medullary thyroid carcinoma excised under thyroxine treatment presented with a painful enlarging lesion on his right heel since one year. A 3-cm diameter, greyish, infiltrated nodule with spicules was seen on physical examination (Fig. 1a). A 5-mm surgical excision was made and a total skin graft was used for reconstruction. Histopathology of the total resected tumour revealed pseudoepitheliomatous hyperplasic epidermis and a proliferation located between rete ridges, dermis and superficial hypodermis (Fig. 1b). The proliferation was composed of nets and cordons of cells with granular and abundant PAS-positive cytoplasm. Immunostains showed cytoplasmic positivity for s100 and inhibin (Fig. 1c). Three years later the patient is asymptomatic.spaTalónInhibinasNeoplasiasProteínas de transporte de noradrenalina a través de la membrana plasmáticaTrasplante de pielTejido subcutáneoTiroxinaTumor de células granularesMedical Subject Headings::Anatomy::Integumentary System::Skin::DermisMedical Subject Headings::Anatomy::Body Regions::Extremities::Lower Extremity::Foot::HeelMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::InhibinsMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Pumps::Symporters::Norepinephrine Plasma Membrane Transport ProteinsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical ExaminationMedical Subject Headings::Anatomy::Integumentary System::SkinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Tissue Transplantation::Skin TransplantationMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Subcutaneous TissueMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones::ThyroxineMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Granular Cell Tumorresearch article26337226open access10.2340/00015555-22371651-2057