Lopez-Medina, ClementinaMolto, AnnaSieper, JoachimDuruöz, TuncayKiltz, UtaElzorkany, BasselHajjaj-Hassouni, NajiaBurgos-Vargas, RubenMaldonado-Cocco, JoseZiade, NellyGavali, MeghnaNavarro-Compan, VictoriaLuo, Shue-FenMonti, SaraTae-Jong, KimKishimoto, MitsumasaPimentel-Santos, F MGu, JieruoSchiotis, Ruxandravan Gaalen, Floris AGeher, PalMagrey, MarinaIbañez Vodnizza, Sebastian EBautista-Molano, WilsonMaksymowych, WalterMachado, Pedro MLandewe, Robertvan der Heijde, DesireeDougados, Maxime2023-02-092023-02-092020-12-12López-Medina C, Molto A, Sieper J, Duruöz T, Kiltz U, Elzorkany B, et al. Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study. RMD Open. 2021 Jan;7(1):e001450http://hdl.handle.net/10668/16989To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive arthritis or juvenile SpA (Juv-SpA)) fitted the patient best. Peripheral manifestations (ie, peripheral joint disease, enthesitis, dactylitis and root joint disease), their localisation and treatments were evaluated. A total of 4465 patients were included (61% men, mean age 44.5 years) from four geographic areas: Latin America (n=538), Europe plus North America (n=1677), Asia (n=975) and the Middle East plus North Africa (n=1275). Of those, 78% had ever suffered from at least one peripheral musculoskeletal manifestation; 57% had peripheral joint disease, 44% had enthesitis and 15% had dactylitis. Latin American had far more often peripheral joint disease (80%) than patients from other areas. Patients with PsA had predominantly upper limb and small joint involvement (52%).Hip and shoulder involvement was found in 34% of patients. The prevalence of enthesitis ranged between 41% in patients with axSpA and 65% in patients with Juv-SpA. Dactylitis was most frequent among patients with PsA (37%). These results suggest that all peripheral features can be found in all subtypes of SpA, and that differences are quantitative rather than qualitative. In a high proportion of patients, axial and peripheral manifestations coincided. These findings reconfirm SpA clinical subtypes are descendants of the same underlying disease, called SpA.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/AnkylosingArthritisJuvenilePsoriaticSpondylitisAdultArthritis, psoriaticCross-sectional studiesFemaleHumansMalePrevalenceSpondylarthritisSpondylitis, ankylosingresearch article33462157open accessArtritis psoriásicaEspondilitis anquilosanteEspondiloartritisEstudios transversalesPrevalencia10.1136/rmdopen-2020-0014502056-5933PMC7816910https://rmdopen.bmj.com/content/rmdopen/7/1/e001450.full.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816910/pdf