Rua-Figueroa, IñigoLopez-Longo, JavierGalindo-Izquierdo, MariaCalvo-Alen, JaimeDel-Campo, VictorOlive-Marques, AlejandroPerez-Vicente, SabinaFernandez-Nebro, AntonioAndres, MarianoErausquin, CeliaTomero, EvaHorcada, LoretoUriarte, EstherFreire, MercedesMontilla, CarlosSanchez-Atrio, AnaSantos, GregorioBoteanu, AlinaDiez-Alvarez, ElviraNarvaez, JavierMartinez-Taboada, VictorSilva-Fernandez, LuciaRuiz-Lucea, EstherAndreu, Jose LuisHernandez-Beriain, Jose AngelGantes, MarianHernandez-Cruz, BlancaPerez-Venegas, JosePecondon-Español, AngelaMarras, CarlosIbañez-Barcelo, MonicaBonilla, GemaTorrente, VicenteCastellvi, IvanAlegre, Juan JoseCalvet, JoanMarenco, Jose LuisRaya, EnriqueVazquez, TomásQuevedo, VictorMuñoz-Fernandez, SantiagoRodriguez-Gomez, ManuelIbañez, JesusPego-Reigosa, Jose M2023-01-252023-01-252017-07-26Rúa-Figueroa Í, López-Longo J, Galindo-Izquierdo M, Calvo-Alén J, Del Campo V, Olivé-Marqués A, et al. Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus. Semin Arthritis Rheum. 2017 Aug;47(1):38-45http://hdl.handle.net/10668/10932To estimate the incidence of severe infection and investigate the associated factors and clinical impact in a large systemic lupus erythematosus (SLE) retrospective cohort. All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria were retrospectively investigated for severe infections. Patients with and without infections were compared in terms of SLE severity, damage, comorbidities, and demographic characteristics. A multivariable Cox regression model was built to calculate hazard ratios (HRs) for the first infection. A total of 3658 SLE patients were included: 90% female, median age 32.9 years (DQ 9.7), and mean follow-up (months) 120.2 (±87.6). A total of 705 (19.3%) patients suffered ≥1 severe infection. Total severe infections recorded in these patients numbered 1227. The incidence rate was 29.2 (95% CI: 27.6-30.9) infections per 1000 patient years. Time from first infection to second infection was significantly shorter than time from diagnosis to first infection (p Severe infection constitutes a predictor of poor prognosis in SLE patients, is more common in Latin-Americans and is associated with age, previous infection, and smoking. Antimalarials exerted a protective effect.enAntimalarialsInfectionSystemic lupus erythematosusÁrea de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de CádizÁrea de Gestión Sanitaria Sur de SevillaAdrenal Cortex HormonesAdultAntimalarialsAntirheumatic AgentsFemaleHumansImmunosuppressive AgentsIncidenceInfectionsLupus Erythematosus, SystemicMaleMycophenolic AcidProportional Hazards ModelsRetrospective StudiesRisk FactorsSeverity of Illness Indexresearch article28259425Restricted AccessInfeccionesIncidenciaReumatologíaFumarLupus Eritematoso Sistémico10.1016/j.semarthrit.2017.01.0101532-866Xhttps://repositorio.unican.es/xmlui/bitstream/10902/13001/1/IncidenceAssociatedFactors.pdf