Hidalgo-Tenorio, CarmenVinuesa, DavidPlata, AntonioMartin-Davila, PilarIftimie, SimonaSequera, SergioLoeches, BelenLopez-Cortes, Luis EduardoFariñas, Mari CarmenFernandez-Roldan, ConcepcionJavier-Martinez, RosarioMuñoz, PatriciaArenas-Miras, Maria Del MarMartinez-Marcos, Francisco JavierMiro, Jose MariaHerrero, CarmenBereciartua, ElenaDe-Jesus, Samantha EPasquau, Juan2023-02-082023-02-082019-10-19Hidalgo-Tenorio C, Vinuesa D, Plata A, Martin Dávila P, Iftimie S, Sequera S, et al. DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci. Ann Clin Microbiol Antimicrob. 2019 Oct 19;18(1):30http://hdl.handle.net/10668/15000To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), as well as its safety and pharmacoeconomic impact. A multicentre, observational and retrospective study was conducted of hospitalised patients with IE and/or BSI produced by GPC who received at least one dose of DBV. Clinical response was assessed during hospitalization, at 3 months and at 1 year. Eighty-three patients with median age of 73 years were enrolled; 73.5% were male; 59.04% had BSI and 49.04% IE (44.04% prosthetic valve IE, 32.4% native IE, 23.5% pacemaker lead). The most frequently isolated microorganism was Staphylococcus aureus in BSI (49%) and coagulase-negative staphylococci in IE (44.1%). All patients with IE were clinically cured in hospital; at 12 months, there was 2.9% loss to follow-up, 8.8% mortality unrelated to IE, and 2.9% therapeutic failure rate. The percentage effectiveness of DBV to treat IE was 96.7%. The clinical cure rate for BSI was 100% during hospital stay and at 3 months; there were no recurrences or deaths during the follow-up. No patient discontinued treatment for adverse events. The saving in hospital stay was 636 days for BSI (315,424.20€) and 557 days for IE (283,187.45€). DBV is an effective consolidation antibiotic therapy in clinically stabilized patients with IE and/or BSI. It proved to be a cost-effective treatment, reducing the hospital stay, thanks to the pharmacokinetic/pharmacodynamic profile of this drug.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Bloodstream infectionDalbavancinEndocarditisAgedAnti-Bacterial AgentsCost-Benefit AnalysisDrug-Related Side Effects and Adverse ReactionsEndocarditis, BacterialFemaleGram-Positive Bacterial InfectionsHumansLength of StayMaleMiddle AgedRetrospective StudiesSepsisTeicoplaninTreatment Outcomeresearch article31629409open accessTiempo de InternaciónDosificaciónAntibacterianosSepsisEndocarditisCuración en Homeopatía10.1186/s12941-019-0329-61476-0711PMC6800500https://doi.org/10.1186/s12941-019-0329-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800500/pdf