Sanchez-Diaz, ManuelLobato-Cano, RubenSalvador-Rodriguez, LuisLopez-Delgado, DavidEspadafor-Lopez, BeatrizVilchez-Marquez, FranciscoRamos-Pleguezuelos, FranciscoMolina-Leyva, AlejandroArias-Santiago, Salvador2023-05-032023-05-032022Sánchez-Díaz M, Lobato-Cano R, Salvador-Rodríguez L, Lopez-Delgado D, Espadafor-Lopez B, Vilchez-Marquez F, et al. Scleredema developing after SARS-CoV-2 infection: a possible novel skin manifestation of coronavirus disease. Eur J Dermatol. 2022 Feb 1;32(1):124-145.http://hdl.handle.net/10668/20453Scleredema is an uncommon sclerodermiform condition characterized by progressive thickening and hardening of the skin involving the neck, shoulders, proximal upper limbs and eventually the face. The diagnosis is based on the appearance of characteristic skin lesions and consistent histology [1]. Scleredema can be classified into three subtypes (see supplementary table 1) [1-6]. The scientific evidence regarding its treatment is scarce and therapeutic guidelines are mainly based on expert opinion [6]. To the best of our knowledge, we report the first case of a patient with scleredema that appeared subsequent to COVID-19. A 47-year-old man had a history of obesity, COVID-19 from which he had recovered, and hepatitis B and C. He had no diabetes mellitus. After a positive SARS-CoV-2 PCR test, the patient presented with dyspnoea and fever. Complementary tests ruled out pneumonia, and he was discharged from the hospital. One week later, the patient improved and COVID-19-related symptoms disappeared.enSARS-CoV-2HumansShoulderSkin DiseasesCOVID-19Scleredema AdultorumPatient DischargeExpert TestimonyCOVID-19Upper ExtremityDiabetes MellitusPolymerase Chain ReactionDyspneaHepatitis Bresearch article35514098Restricted AccessAlta del pacienteDiabetes mellitusDisneaEscleredema del adultoExtremidad superiorHepatitis BReacción en cadena de la polimerasaTestimonio de experto10.1684/ejd.2021.41911952-4013PMC9170550https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170550https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170550/pdf