Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America

Torres, M JRomano, ACelik, GDemoly, PKhan, D AMacy, EPark, MBlumenthal, KAberer, WCastells, MBarbaud, AMayorga, CBonadonna, P2017-05-292017-05-292017-03-13Torres MJ, Romano A, Celik G, Demoly P, Khan DA, Macy E, et al. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy. 2017; 13;7:7.http://hdl.handle.net/10668/2681Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests. Although over the years both European and U.S. experts have published statements on general procedures for evaluating DHRs, a substantial discordance in their daily management exists. In this review, we highlight both the differences and the similarities between the European and U.S.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DrugHypersensitivityAllergyDiagnosisSkin testIn vitro testIgET-cellsDrug provocation testSensitizationUnit StatesEuropeMedical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::AnaphylaxisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Drug EvaluationMedical Subject Headings::Diseases::Chemically-Induced Disorders::Drug-Related Side Effects and Adverse Reactions::Drug HypersensitivityMedical Subject Headings::Health Care::Population Characteristics::Demography::Ethnic GroupsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Health Care::Population Characteristics::Health::Public HealthMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Skin TestsMedical Subject Headings::Geographical Locations::Geographic Locations::Americas::North America::United StatesMedical Subject Headings::Geographical Locations::Geographic Locations::EuropeApproach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North Americaresearch article28293415open accessAnafilaxiaEvaluación de MedicamentosHipersensibilidad a las drogasGrupos étnicosSalud públicaPruebas cutáneas10.1186/s13601-017-0144-02045-7022PMC5347172