Sartelli, MassimoCatena, FaustoAnsaloni, LucaCoccolini, FedericoCorbella, DavideMoore, Ernest EMalangoni, MarkVelmahos, GeorgeCoimbra, RaulKoike, KaoruLeppaniemi, AriBiffl, WalterBalogh, ZsoltBendinelli, CinoGupta, SanjayKluger, YoramAgresta, FerdinandoDi Saverio, SalomoneTugnoli, GregorioJovine, ElioOrdonez, Carlos AWhelan, James FFraga, Gustavo PGomes, Carlos AugustoPereira, Gerson AlvesYuan, Kuo-ChingBala, MikloshPeev, Miroslav PBen-Ishay, OffirCui, YunfengMarwah, SanjayZachariah, SanoopWani, ImtiazRangarajan, MuthukumaranSakakushev, BorisKong, VictorAhmed, AdamuAbbas, AshrafGonsaga, Ricardo Alessandro TeixeiraGuercioni, GianlucaVettoretto, NereoPoiasina, EliaDíaz-Nieto, RafaelMassalou, DamienSkrovina, MatejGerych, IhorAugustin, GoranKenig, JakubKhokha, VladimirTranà, CristianKok, Kenneth Yuh YenMefire, Alain ChichomLee, Jae GilHong, Suk-KyungLohse, Helmut Alfredo SegoviaGhnnam, WagihVerni, AlfredoLohsiriwat, VarutSiribumrungwong, BoonyingEl Zalabany, TamerTavares, AlbertoBaiocchi, GianlucaDas, KorayJarry, JulienZida, MauriceSato, NorioMurata, KiyoshiShoko, TomohisaIrahara, TakayukiHamedelneel, Ahmed ONaidoo, NoelAdesunkanmi, Abdul Rashid KayodeKobe, YoshiroIshii, WataruOka, KazuyukiIzawa, YoshimitsuHamid, HythamKhan, IqbalAttri, AkSharma, RajeevSanjuán, JuanBadiel, MarisolBarnabé, Rita2015-01-232015-01-232014-05-14Sartelli M, Catena F, Ansaloni L, Coccolini F, Corbella D, Moore EE, et al. Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study. World Journal of Emergency Surgery. 2014; 9:37http://hdl.handle.net/10668/1798Journal Article;The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).enInfecciones intraabdominalesEstudio multicéntricoAbsceso abdominalEnfermedad críticaHumanosDrenajeProcedimientos quirúrgicos del sistema digestivoFarmacoresistencia microbianaReoperaciónInfección hospitalariaAdultoMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Intraabdominal InfectionsMedical Subject Headings::Publication Characteristics::Study Characteristics::Multicenter StudyMedical Subject Headings::Diseases::Digestive System Diseases::Peritoneal Diseases::PeritonitisMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Suppuration::Abscess::Abdominal AbscessMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Critical IllnessMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::DrainageMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Digestive System Surgical ProceduresMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, MicrobialMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::SepsisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::ReoperationMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross InfectionMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article24883079open access10.1186/1749-7922-9-371749-7922PMC4039043