Carrasco Hernández, LauraCaballero Eraso, CandelaRuiz-Duque, BorjaAbad Arranz, MaríaMárquez Martín, EduardoCalero Acuña, CarmenLopez-Campos, Jose Luis2025-01-072025-01-072021-04-152077-0383https://hdl.handle.net/10668/27503Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deteriorationenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COPDclinical responselong-acting bronchodilatorspharmacologicalresearch article33921051open access10.3390/jcm10081708PMC8071403https://www.mdpi.com/2077-0383/10/8/1708/pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8071403/pdf