Alonso, SRiveiro-Barciela, MFernandez, IRincon, DReal, YLlerena, SGea, FOlveira, AFernandez-Carrillo, CPolo, BCarrion, J AGomez, ADevesa, M JBaliellas, CCastro, AAmpuero, JGranados, RPascasio, J MRubin, ASalmeron, JBadia, EPlanas, J M MLens, STurnes, JMontero, J LButi, MEsteban, RFernandez-Rodriguez, C M2023-01-252023-01-252017-03-26Alonso S, Riveiro-Barciela M, Fernandez I, Rincón D, Real Y, Llerena S, et al. Effectiveness and safety of sofosbuvir-based regimens plus an NS5A inhibitor for patients with HCV genotype 3 infection and cirrhosis. Results of a multicenter real-life cohort. J Viral Hepat. 2017 Apr;24(4):304-311.http://hdl.handle.net/10668/10667Patients with HCV genotype 3 (GT3) infection and cirrhosis are currently the most difficult to cure . We report our experience with sofosbuvir +daclatasvir (SOF+DCV) or sofosbuvir /ledipasvir (SOF/LDV), with or without ribavirin (RBV) in clinical practice in this population . This was a multicenter observational study including cirrhotic patients infected by HCV GT3, treated with sofosbuvir plus an NS5A inhibitor (May 2014-October 2015). In total, 208 patients were included: 98 (47%) treatment -experienced, 42 (20%) decompensated and 55 (27%) MELD score >10. In 131 (63%), treatment was SOF+DCV and in 77 (37%), SOF/LDV. Overall, 86% received RBV. RBV addition and extension to 24 weeks was higher in the SOF/LDV group (95% vs 80%, P=.002 and 83% vs 72%, P=.044, respectively). A higher percentage of decompensated patients were treated with DCV than LDV (25% vs 12%, P=.013). Overall, SVR12 was 93.8% (195/208): 94% with SOF+DCV and 93.5% with SOF/LDV. SVR12 was achieved in 90.5% of decompensated patients . Eleven treatment failures : 10 relapses and one breakthrough. RBV addition did not improve SVR (RR: 1.08; P=.919). The single factor associated with failure to achieve SVR was platelet count <75×10E9/mL (RR: 3.50, P=.019). In patients with MELD <10, type of NS5A inhibitor did not impact on SVR12 (94% vs 97%; adjusted RR: 0.49). Thirteen patients (6.3%) had serious adverse events, including three deaths (1.4%) and one therapy discontinuation (0.5%), higher in decompensated patients (16.7% vs 3.6%, P<.006). In patients with GT3 infection and cirrhosis , SVR12 rates were high with both SOF+DCV and SOF/LDV, with few serious adverse events.enSVR12cirrhosisdaclatasvirgenotype 3hepatitis Cledipasvirobservational studyreal-world cohortAdultAgedAged, 80 and overAntiviral AgentsFemaleGenotypeHepacivirusHepatitis C, ChronicHumansLiver CirrhosisMaleMiddle AgedRibavirinSofosbuvirTreatment OutcomeViral Nonstructural ProteinsYoung Adultresearch article27935168Restricted AccessPacientesSofosbuvirInfeccionesFibrosisGenotipoCuración HomeopáticaInsuficiencia del tratamientoRibavirinaRecurrenciaRecuento de plaquetas10.1111/jvh.126481365-2893https://ruc.udc.es/dspace/bitstream/2183/21063/2/Also_Effctvness.pdf