Diaz-Lopez, AndresBecerra-Tomas, NereaRuiz, VeronicaToledo, EstefaniaBabio, NancyCorella, DoloresFito, MontseRomaguera, DoraVioque, JesusAlonso-Gomez, Angel MWärnberg, JuliaMartinez, J AlfredoSerra-Majem, LuisEstruch, RamonTinahones, Francisco JLapetra, JosePinto, XavierTur, Josep ALopez-Miranda, JoseCano Ibañez, NaomiDelgado-Rodriguez, MiguelMatia-Martin, PilarDaimiel, Lidiade Paz, Jose AntonioVidal, JosepVazquez, ClotildeRuiz-Canela, MiguelBullo, MonicaSorli, Jose VGoday, AlbertFiol, MiquelGarcia-de-la-Hera, ManoliTojal Sierra, LucasPerez-Farinos, NapoleonZulet, Maria AngelesSanchez-Villegas, AlmudenaSacanella, EmilioFernandez-Garcia, Jose CarlosSantos-Lozano, Jose ManuelGimenez-Gracia, MiquelDel Mar Bibiloni, MariaDiez-Espino, JavierOrtega-Azorin, CarolinaCastañer, OlgaMorey, MargaTorres-Collado, LauraSorto Sanchez, CarolinaMuñoz, Miguel AngelRos, EmilioMartinez-Gonzalez, Miguel ASalas-Salvado, Jordi2023-02-092023-02-0920210-12-0Díaz-López A, Becerra-Tomás N, Ruiz V, Toledo E, Babio N, Corella D, et al. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. Am J Nephrol. 2021;52(1):45-58http://hdl.handle.net/10668/17123Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Randomized controlled "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR ( After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.enDietary interventionGlomerular filtration rateKidney functionMediterranean dietPREDIMED-PlusWeight lossAgedFemaleHumansKidneyKidney function testsLife styleMaleMiddle agedObesityWeight lossresearch article33556935open accessAncianoEstilo de vidaObesidadPruebas de función renalPérdida de pesoRiñón10.1159/0005136641421-9670https://www.karger.com/Article/Pdf/513664