Rodríguez-Sojo, María JesúsRuiz-Malagón, Antonio JesúsRodríguez-Cabezas, María ElenaGálvez, JulioRodríguez-Nogales, Alba2022-03-072022-03-072021-03-21Rodríguez-Sojo MJ, Ruiz-Malagón AJ, Rodríguez-Cabezas ME, Gálvez J, Rodríguez-Nogales A. Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights. Nutrients. 2021;13(3):1016.http://hdl.handle.net/10668/3463Probiotics microorganisms exert their health-associated activities through some of the following general actions: competitive exclusion, enhancement of intestinal barrier function, production of bacteriocins, improvement of altered microbiota, and modulation of the immune response. Among them, Limosilactobacillus fermentum CECT5716 has become one of the most promising probiotics and it has been described to possess potential beneficial effects on inflammatory processes and immunological alterations. Different studies, preclinical and clinical trials, have evidenced its anti-inflammatory and immunomodulatory properties and elucidated the precise mechanisms of action involved in its beneficial effects. Therefore, the aim of this review is to provide an updated overview of the effect on host health, mechanisms, and future therapeutic approaches.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/ProbioticLimosilactobacillus fermentum CECT5716ImmunomodulationDysbiosisMechanisms of actionGastrointestinal diseasesMicrobiotaProbióticosInmunomodulaciónDisbiosisMecanismos moleculares de acción farmacológicaEnfermedades gastrointestinalesMicrobiotaMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal DiseasesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::ImmunomodulationMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::LactobacillaceaeMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::LactobacillalesMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::ProbioticsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Bacteriocinsreview article33801082open access10.3390/nu130310162072-6643PMC8003974