Rubio-Rivas, ManuelCorbella, XavierFormiga, FrancescMenéndez Fernández, EstelaMartín Escalante, María DoloresBaños Fernández, IsolinaArnalich Fernández, FranciscoDel Corral-Beamonte, EstherLalueza, AntonioParra Virto, AlejandroRoy Vallejo, EmiliaLoureiro-Amigo, JoséÁlvarez Suárez, Ana MaríaAbadía-Otero, JesicaNavarro De La Chica, MaríaEstévez González, RaquelHernández Milián, AlmudenaAreses Manrique, MaríaBlázquez Encinar, Julio CésarGonzález Noya, AmaraGonzález Ferrer, RuthPérez Aguilera, MaríaGil Sánchez, RicardoMillán Núñez-Cortés, JesúsCasas-Rojo, José ManuelOn Behalf Of The Semi-Covid-Network,2023-02-092023-02-092021-05-202077-0383http://hdl.handle.net/10668/17880(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19cytokine stormmortalityprognosisrisk factorsresearch article34065316open access10.3390/jcm10102214PMC8161115https://www.mdpi.com/2077-0383/10/10/2214/pdf?version=1621502692https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161115/pdf